Alternative Integrated Testing for Skin Sensitization: Assuring Consumer Safety
نویسندگان
چکیده
منابع مشابه
Assuring safety without animal testing: Unilever's ongoing research programme to deliver novel ways to assure consumer safety.
Assuring consumer safety without the generation of new animal data is currently a considerable challenge. However, through the application of new technologies and the further development of risk-based approaches for safety assessment, we remain confident it is ultimately achievable. For many complex, multi-organ consumer safety endpoints, the development, evaluation and application of new, non-...
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Non-animal test methods for skin sensitization have to consider the complex interactions of chemicals with the different parts of the skin immune system (Cumberbatch et al., 1992). A few chemicals act as prohaptens and can be converted to a hapten by oxidation, skin metabolism, or ultraviolet radiation (Karschuk et al., 2010). the hapten (parent or converted chemical) may penetrate the skin and...
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Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin-sensitization potential of chemicals. In addition to accurate identification of skin sensitizers, the LLNA can also provide a reliable measure of relative sensitization...
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The paper provides an overview of existing Integrated Testing Strategies (ITS) for assessing hazard and potency of skin sensitization. The ITS research is active, diverse and constantly evolving as new assays are being developed and new mechanistic insights are discovered. Despite the need to assess potency, the majority of the ITS approaches developed to date assess hazard only. Reasons for th...
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INTRODUCTION Skin sensitization forms a major toxicological endpoint for dermatology and cosmetic products. Recent ban on animal testing for cosmetics demands for alternative methods. We developed an integrated computational solution (SkinSense) that offers a robust solution and addresses the limitations of existing computational tools i.e. high false positive rate and/or limited coverage. RE...
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ژورنال
عنوان ژورنال: Applied In Vitro Toxicology
سال: 2018
ISSN: 2332-1512,2332-1539
DOI: 10.1089/aivt.2017.0023